ACRL leads the way

Membrane tension leads the way.

T ension in the plasma membrane of adherent cells arises from the in-plane tension in the lipid bilayer, as well as from the adhesion between the membrane and the cytoskeleton (1). The membrane tension exerts a force along the cell boundary that affects all processes involving membrane deformations, including edge extension, endocytosis, and exocytosis. As such, membrane tension has been implic...

Once again, complex care leads the way.

Ninein leads the way in vessel sprouting.

Ninein Leads the Way in Vessel Sprouting Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2008 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/ATVBAHA.108.17618

Salmonella vacuole maturation: PIKfyve leads the way.

In this issue of The EMBO Journal, a study from Rohan Teasdale’s laboratory provides evidence that PIKfyve, a PtdIns D5-kinase, is required for maturation of Salmonellacontaining vacuole (SCV) and Salmonella replication. This report sheds light on a novel mechanism that mediates fusion of both macropinosomes and SCV with lysosomal/ late endosomal organelles. Bacterial intracellular pathogens ha...

Cell Mechanics: FilaminA Leads the Way

Actin filaments are thought to be the major structural components of most eukaryotic cells, but reconstituted actin networks have yet to account for the remarkable strength exhibited by cellular networks. A new study has found that reconstituted networks that include the cross-linker filaminA can replicate many of the mechanical properties of cells if they are stressed prior to mechanical measu...